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Irbesartan blocks the vasoconstrictor and aldosterone-secreting consequences of angiotensin II by selectively binding towards the AT1 angiotensin II receptor. There's also an AT2 receptor in many tissues, but It isn't linked to cardiovascular homeostasis.
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Usually, sodium is reabsorbed into epithelial cells of your distal convoluted tubule and pumped to the basolateral interstitium by a sodium-potassium ATPase, developing a focus gradient in between the epithelial cell as well as distal convoluted tubule that promotes the reabsorption of h2o.
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